| Evidence: |
- Tissue injury measured by Injury Severity Score (ISS) is correlated with PT-based (0.14, p< 0.001) and PTT-based coagulopathy (0.23, p<0.001)
[References]
- Coagulopathy is associated with combination of tissue hypoperfusion and tissue injury in a mice model
[References]
- Coagulopathy developed in rats subjected to haemorrhagic shock and tissue perfusion.
[References]
- Tissue injury, measured by Injury Severity Score (ISS), is strongly associated with coagulopathy.
[References]
- Patients with severe tissue injury but no physiologic derangement rarely present with a coagulopathy. Tissue trauma is, therefore, an initiator of coagulation, but in isolation is rarely responsible for clinical coagulopathy.
[References]
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