| Evidence: |
- Hypoperfusion appears to be a primary driver of trauma coagulopathy. Acute traumatic coagulopathy is only evident in the presence of tissue hypoperfusion
[References]
- Coagulopathy is associated with combination of tissue hypoperfusion and tissue injury in a mice model
[References]
- Coagulopathy developed in rats subjected to haemorrhagic shock and tissue perfusion.
[References]
- Patients with severe tissue injury but no physiologic derangement rarely present with a coagulopathy. Tissue trauma is, therefore, an initiator of coagulation, but in isolation is rarely responsible for clinical coagulopathy.
[References]
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