Evidence Browser: Relation: Hypoperfusion → PH
- Lactic acidosis results from tissue hypoxia resulting from hypoperfusion. Cells undergoing anaerobic respiration generate lactic acid. The degree of lactic acidosis is a sensitive measure of the degree of shock / tissue hypoperfusion.
- Increasing severity of shock (worsening tissue hypoperfusion) is associated with increasing heart rate (HR), worsening hypotension and worsening metabolic acidosis.